基于文献的舒肝解郁胶囊临床应用文本挖掘研究
[摘要] 該研究主要分析舒肝解郁胶囊的临床应用特点，通过文本挖掘技术检索中文生物医学期刊数据库，搜集关于舒肝解郁胶囊的论文数据，利用基于关键词频数统计的数据分层方法，挖掘数据集中证型、疾病、症状、联用药物等方面的信息。挖掘结果通过一维频次并构建联系图进行展示。通过挖掘共检索出190篇舒肝解郁胶囊相关的论文。分析显示舒肝解郁胶囊的临床使用多与肝郁、气滞等证型类别相关；舒肝解郁胶囊运用的主要疾病包括原发性抑郁发作、脑器质性抑郁障碍、躯体疾病伴发抑郁、功能性消化不良、精神分裂症伴发抑郁等精神科、心身科疾病；舒肝解郁胶囊主治的症状包括情绪低落、精神性焦虑、躯体性焦虑、自主神经功能紊乱等；舒肝解郁胶囊常与帕罗西汀、舍曲林、氟西汀等药物联合使用。研究结果提示舒肝解郁胶囊治疗的证型、疾病等挖掘分析结果与其说明书中基本吻合，潜在治疗证型为心神失养证，潜在治疗疾病为躯体疾病伴发抑郁焦虑共病、原发性抑郁焦虑共病、产后抑郁等。其常见联用药物为帕罗西汀、舍曲林、氟西汀。
[关键词] 文本挖掘； 舒肝解郁胶囊； 中医药； 治疗
Exploring the clinical characters of Shugan Jieyu capsule through text mining
PU Zhengping1，2， XIA Jiangming2， XIE Wei3， HE Jincai1*
（1. Graduate School， Wenzhou Medical University， Wenzhou 325035， China；
2. Department of Psychiatry， Kangci Hospital of Jiaxing， Jiaxing 314500， China；
3. Department of Automation， Tsinghua University， Beijing 100084， China）
[Abstract] The study was main to explore the clinical characters of Shugan Jieyu capsule through text mining. The data sets of Shugan Jieyu capsule were downloaded from CMCC database by the method of literature retrieved from May 2009 to Jan 2016. Rules of Chinese medical patterns， diseases， symptoms and combination treatment were mined out by data slicing algorithm， and they were demonstrated in frequency tables and two dimension based network. Then totally 190 literature were recruited. The outcomess suggested that SC was most frequently correlated with liver Qi stagnation. Primary depression， depression due to brain disease， concomitant depression followed by physical diseases， concomitant depression followed by schizophrenia and functional dyspepsia were main diseases treated by Shugan Jieyu capsule. Symptoms like low mood， psychic anxiety， somatic anxiety and dysfunction of automatic nerve were mainy relieved bv Shugan Jieyu capsule.For combination treatment. Shugan Jieyu capsule was most commonly used with paroxetine， sertraline and fluoxetine. The research suggested that syndrome types and mining results of Shugan Jieyu capsule were almost the same as its instructions. Syndrome of malnutrition of heart spirit was the potential Chinese medical pattern of Shugan Jieyu capsule. Primary comorbid anxiety and depression， concomitant comorbid anxiety and depression followed by physical diseases， and postpartum depression were potential diseases treated by Shugan Jieyu capsule.For combination treatment， Shugan Jieyu capsule was most commonly used with paroxetine， sertraline and fluoxetine.
[Key words] text mining； Shugan Jieyu capsule； traditional Chinese medicine； treatment